Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506.

Immunosuppression is currently used for allotransplantation, and is being evaluated for the treatment of insulin-dependent diabetes mellitus and other autoimmune diseases. However, most available agents have a number of side effects that limit their use in clinical situations. It has been shown previously, for example, that cyclosporine may inhibit insulin… (More)