Inhibition of glucose phosphate isomerase by metabolic intermediates of fructose.

@article{Zalitis1967InhibitionOG,
  title={Inhibition of glucose phosphate isomerase by metabolic intermediates of fructose.},
  author={J G Zalitis and I T. Oliver},
  journal={The Biochemical journal},
  year={1967},
  volume={102 3},
  pages={753-9}
}
1. Purified rabbit-muscle and -liver glucose phosphate isomerase, free of contaminating enzyme activities that could interfere with the assay procedures, were tested for inhibition by fructose, fructose 1-phosphate and fructose 1,6-diphosphate. 2. Fructose 1-phosphate and fructose 1,6-diphosphate are both competitive with fructose 6-phosphate in the enzymic reaction, the apparent K(i) values being 1.37x10(-3)-1.67x10(-3)m for fructose 1-phosphate and 7.2x10(-3)-7.9x10(-3)m for fructose 1,6… CONTINUE READING