Inhibition of glucose-induced insulin release by 3-O-methyl-D-glucose: Enzymatic, metabolic and cationic determinants

@article{Sener1999InhibitionOG,
  title={Inhibition of glucose-induced insulin release by 3-O-methyl-D-glucose: Enzymatic, metabolic and cationic determinants},
  author={Abdullah Sener and Olivier Scruel and Karim Louchami and Hassan Jijakli and Willy J Malaisse},
  journal={Molecular and Cellular Biochemistry},
  year={1999},
  volume={194},
  pages={133-145}
}
The analog of D-glucose, 3-O-methyl-D-glucose, is thought to delay the equilibration of D-glucose concentration across the plasma membrane of pancreatic islet B-cells, but not to exert any marked inhibitory action upon the late phase of glucose-stimulated insulin release. In this study, however, 3-O-methyl-D-glucose, when tested in high concentrations (30-80 mM) was found to cause a rapid, sustained and not rapidly reversible inhibition of glucose-induced insulin release in rat pancreatic… CONTINUE READING

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