Inhibition of glucose 6-phosphate dehydrogenase by palmitoyl coenzyme A.

@article{Kawaguchi1974InhibitionOG,
  title={Inhibition of glucose 6-phosphate dehydrogenase by palmitoyl coenzyme A.},
  author={Akihiko Kawaguchi and Konrad Bloch},
  journal={The Journal of biological chemistry},
  year={1974},
  volume={249 18},
  pages={5793-800}
}
Low concentrations of palmitoyl coenzyme A inhibit yeast glucose-6-P dehydrogenase (TAKETA, K., AND POGELL, B. M. (1966) J. Biol. Chem. 241, 720). This inhibition is prevented or reversed by bovine serum albumin, mycobacterial polysaccharides, or alkylated cyclodextrins. Sephadex chromatography and sucrose density gradient centrifugation show that palmitoyl-CoA inhibits by dissociating the tetramerit dehydrogenase to dimeric, enzymatically inactive subunits. These structural changes are… CONTINUE READING

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