Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase.

@article{Berasi2006InhibitionOG,
  title={Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase.},
  author={Stephen P. Berasi and Christine Huard and Dongmei Li and Heather H. Shih and Ying Sun and Wenyan Zhong and Janet E. Paulsen and Eugene L. Brown and Ruth E. Gimeno and Robert Vincent P Martinez},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 37},
  pages={
          27167-77
        }
}
Increased hepatic gluconeogenesis is an important contributor to the fasting hyperglycemia found in Type 2 diabetic patients. Low energy states activate the intracellular energy sensor AMP-activated kinase (AMPK). AMPK activation by the AMP mimetic AICAR (5-aminoimidazole-4-carboxamide riboside) has been shown to inhibit hepatic gluconeogenesis. We used transcriptional profiling to search for AICAR-regulated genes in hepatocyte cell lines. We report that a dual specificity phosphatase, Dusp4… CONTINUE READING
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