Inhibition of glucocorticoid receptor binding by nitric oxide.

  title={Inhibition of glucocorticoid receptor binding by nitric oxide.},
  author={Mario D. Galigniana and Graciela Piwien-Pilipuk and Jamil Assreuy},
  journal={Molecular pharmacology},
  volume={55 2},
Septic shock is a dangerous condition with high mortality rates. In sepsis, the inducible form of nitric oxide (NO) synthase is induced, releasing high amounts of NO. Glucocorticoids have potent anti-inflammatory properties and are very effective in inhibiting the induction of this enzyme if administered before the shock onset. It is known that glucocorticoid receptor (GR) has critical cysteine residues for steroid binding in its hormone-binding and DNA-binding domains. It has also been… CONTINUE READING
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