Inhibition of geranylgeranyltransferase inhibits bronchial smooth muscle hyperresponsiveness in mice.

@article{Chiba2009InhibitionOG,
  title={Inhibition of geranylgeranyltransferase inhibits bronchial smooth muscle hyperresponsiveness in mice.},
  author={Yoshihiko Chiba and Shunsuke Sato and Motohiko Hanazaki and Hiroyasu Sakai and Miwa Misawa},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={297 5},
  pages={L984-91}
}
Recent studies revealed an involvement of RhoA/Rho-kinase in the contraction of bronchial smooth muscle (BSM), and this pathway has now been proposed as a new target for asthma therapy. A posttranslational geranylgeranylation of RhoA is required for its activation. Thus selective inhibition of geranylgeranyltransferase may be a novel strategy for treatment of the BSM hyperresponsiveness in asthmatics. To test this hypothesis, we investigated the effect of a geranylgeranyltransferase inhibitor… CONTINUE READING