Inhibition of gastrin gene expression by somatostatin.

P. S. Karnik; S. J. Monahan; M. Wolfe

DOI:10.1172/JCI113893

Corpus ID: 13603495

Inhibition of gastrin gene expression by somatostatin.

@article{Karnik1989InhibitionOG,
  title={Inhibition of gastrin gene expression by somatostatin.},
  author={P. S. Karnik and S. J. Monahan and M. Wolfe},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={83 2},
  pages={
          367-72
        }
}

P. S. Karnik, S. J. Monahan, M. Wolfe
Published 1989
Biology, Medicine
The Journal of clinical investigation

Previous studies performed in this laboratory have demonstrated somatostatin-containing cells in close proximity to gastrin cells in antral mucosa and have shown that somatostatin exerts a local regulatory effect on gastrin release. The present studies were directed to determine whether the effects of somatostatin on the antral gastrin cell involve pretranslational events. The effects of somatostatin on gastrin mRNA were determined by dot blot hybridization using a gastrin antisense RNA probe… Expand

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