Inhibition of gastric tumorigenesis byα-difluoromethylornithine in rats treated with N-methyl-N′-nitro-N-nitrosoguanidine

Abstract

Male Wistar rats were treated concurrently with a combination of the carcinogenN-methyl-N′-nitro-N-nitrosoguanidine (MNNG; CAS 70-25-7) and the polyamine-synthesis inhibitor α-difluoromethylornithine (DFMO) at two different doses of 0.5% and 1.0% (w/v). Experimental groups were treated with (I) MNNG alone (n=25), (II) MNNG plus 0.5% (w/v) DFMO (n=25), (III… (More)
DOI: 10.1007/BF01372722

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@article{Lehnert1993InhibitionOG, title={Inhibition of gastric tumorigenesis byα-difluoromethylornithine in rats treated with N-methyl-N′-nitro-N-nitrosoguanidine}, author={Thomas Lehnert and Klaus Buhl and Stanislaw Ivankovic}, journal={Journal of Cancer Research and Clinical Oncology}, year={1993}, volume={119}, pages={594-598} }