Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats

  title={Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats},
  author={M L Doong and C. C. Lu and M M Kau and Shiow Chwen Tsai and Y C Chiao and J J Chen and J Y Yeh and H. Lin and S W Huang and T S Chen and Full Young Chang and P. S. Wang},
  journal={British Journal of Pharmacology},
  • M. Doong, C. Lu, P. S. Wang
  • Published 1 July 1998
  • Biology, Medicine, Psychology
  • British Journal of Pharmacology
1 The effect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2 Gastric emptying was inhibited both acutely and chronically by the administration of amphetamine. GI transit was decreased by the acute administration of amphetamine but not affected by the chronic administration of amphetamine. 3 Plasma CCK levels were increased dose‐dependently by amphetamine. 4 Proglumide, a CCK receptor antagonist, prevented amphetamine… 
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It is suggested that OT inhibits gastric emptying and gastrointestinal transit in female rats via a mechanism involving CCK stimulation and CCK1 receptor activation.
Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats
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The Role of Cholecystokinin 1 Receptor in Prolactin Inhibited Gastric Emptying of Male Rat
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Effects of progesterone on gastric emptying and intestinal transit in male rats.
Low dose of P increased GI motility while high doses of P decreased it, and during the later period of pregnancy, elevated plasma level of OT may also participate in the gastrointestinal inhibition.
Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats.
Investigation of the effect of hCG on gastrointestinal transit and plasma concentrations of cholecystokinin (CCK) in ovariectomized (Ovx) rats found that hCG treatment of Ovx rats inhibits gastric emptying in a dose-dependent manner via a peripheral mechanism of CCK hypersecretion and activation ofCCK(1) receptors.
Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats
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Cholecystokinin suppresses food intake by inhibiting gastric emptying.
CCK can be considered a link in a chain of physiological elements producing the short-term satiety that leads to the appropriate interruption of a meal or bout of feeding behavior, and depends upon inhibition of gastric emptying, which then leads to gastric distention with further food injection.
Effects of cholecystokinin and caerulein on gastric emptying.
  • M. Anika
  • Biology, Medicine
    European journal of pharmacology
  • 1982
Effect of Cholecystokinin on Gastric Motility in Humans a
  • C. Beglinger
  • Medicine
    Annals of the New York Academy of Sciences
  • 1994
CCK may play a role as a common regulator of postprandial gallbladder contraction and pancreatic enzyme secretion as well as of gastric emptying rates under certain conditions, which would optimize the nutrient-to-digestive juices concentration ratio.
Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat
  • P. Holzer
  • Medicine, Biology
    British journal of pharmacology
  • 1985
The results show that the effects of substance P and substance K on gastrointestinal propulsion vary with dose and time and involve, at least partly, activation of the autonomic nervous system.
Intestinal phase of human antro‐pyloro‐duodenal motility: cholinergic and CCK‐mediated regulation
It is concluded that both cholinergic input and endogenous CCK are major stimulatory regulators of antro‐pyloroduodenal motility in the intestinal phase and primarily affects smooth muscle receptors in the duodenum.
Induction of postprandial intestinal motility and release of cholecystokinin by polyamines in rats.
It is indicated that exogenous polyamines disrupt intestinal MMCs and stimulate colonic motility through a release of CCK acting at CCK-A andCCK-B receptors and suggest that endogenous polyamines are involved in the postprandial control of intestinal motility.
Fenfluramine anorexia: A peripheral locus of action