Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats

@article{Doong1998InhibitionOG,
  title={Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving an increased secretion of CCK in male rats},
  author={M L Doong and C. C. Lu and M M Kau and Shiow Chwen Tsai and Y C Chiao and J J Chen and J Y Yeh and H. Lin and S W Huang and T S Chen and Full Young Chang and P. S. Wang},
  journal={British Journal of Pharmacology},
  year={1998},
  volume={124}
}
  • M. Doong, C. Lu, P. S. Wang
  • Published 1 July 1998
  • Biology, Medicine, Psychology
  • British Journal of Pharmacology
1 The effect of amphetamine on gastrointestinal (GI) transit and the plasma levels of cholecystokinin (CCK) were studied in male rats. 2 Gastric emptying was inhibited both acutely and chronically by the administration of amphetamine. GI transit was decreased by the acute administration of amphetamine but not affected by the chronic administration of amphetamine. 3 Plasma CCK levels were increased dose‐dependently by amphetamine. 4 Proglumide, a CCK receptor antagonist, prevented amphetamine… 
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