Inhibition of gastric emptying and feeding by fenfluramine.

  title={Inhibition of gastric emptying and feeding by fenfluramine.},
  author={P. Robinson and T. Moran and P. McHugh},
  journal={The American journal of physiology},
  volume={250 5 Pt 2},
To assess the mechanism by which the anorectic agent fenfluramine influences feeding, we examined in Macaca mulatta the effect of intragastric fenfluramine (2 mg/kg) on both feeding and the gastric emptying of saline and glucose test meals. Gastric emptying was measured by the dye-dilution technique, using chronic indwelling intragastric cannulas. The emptying of normal saline was inhibited by fenfluramine as was the initial bolus phase of the emptying of glucose. In contrast, the subsequent… Expand
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