Inhibition of gastric acid secretion in rat stomach by PACAP is mediated by secretin, somatostatin, and PGE(2).

@article{Li2000InhibitionOG,
  title={Inhibition of gastric acid secretion in rat stomach by PACAP is mediated by secretin, somatostatin, and PGE(2).},
  author={P Li and T M Chang and D. H. Coy. E. J. Coy and William Y. Chey},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={278 1},
  pages={G121-7}
}
Pituitary adenylate cyclase-activating polypeptide (PACAP), existing in two variants, PACAP-27 and PACAP-38, is found in the enteric nervous system and regulates function of the digestive system. However, the regulatory mechanism of PACAP on gastric acid secretion has not been well elucidated. We investigated the inhibitory action of PACAP-27 on acid secretion and its mechanism in isolated vascularly perfused rat stomach. PACAP-27 in four graded doses (5, 10, 20, and 50 microg/h) was vascularly… CONTINUE READING