Inhibition of gastric K+/H+-ATPase by acid-activated 2-((2-pyridylmethyl)sulphinyl)benzimidazole products.

Abstract

The inhibitory effects of timoprazole- and omeprazole-derived metabolites were studied in different in vitro test systems in order to characterize the metabolites of substituted benzimidazoles originating from acid activation. Acidification of timoprazole and omeprazole to pH 1.0 markedly increased the inhibitory potency on gastric K+/H+-ATPase. The… (More)

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@article{Beil1987InhibitionOG, title={Inhibition of gastric K+/H+-ATPase by acid-activated 2-((2-pyridylmethyl)sulphinyl)benzimidazole products.}, author={Winfried Beil and Holger Hannemann and S Maedge and K. Fr. Sewing}, journal={European journal of pharmacology}, year={1987}, volume={133 1}, pages={37-45} }