Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet.

Abstract

Propylthiouracil (PTU) or low-iodine diet (LID) treatment increases thyroid-follicular-cell proliferation, possibly by disrupting the movement of small molecules (< 1.2 kD) through membrane channels called gap junctions. Numerous tumor promoters and proliferative disease states exhibit inhibited gap-junctional-intercellular communication (GJIC) prior to the… (More)

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@article{Kolaja2000InhibitionOG, title={Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet.}, author={Kyle Kolaja and Jay S. Petrick and Curtis D. Klaassen}, journal={Toxicology}, year={2000}, volume={143 2}, pages={195-202} }