Inhibition of gap junctional intercellular communication by toxic metals.

  title={Inhibition of gap junctional intercellular communication by toxic metals.},
  author={Mathieu Vinken and Liesbeth Ceelen and Tamara Vanhaecke and Vera Rogiers},
  journal={Chemical research in toxicology},
  volume={23 12},
As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of cellular signaling mediated by gap junctions. This paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminum, lead, nickel, vanadium… CONTINUE READING


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Epigenetic regulation of gap junctional intercellular communication: More than a way to keep cells

  • M. Vinken, E. De Rop, +4 authors V. Rogiers
  • quiet. Biochim. Biophys
  • 2009

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