Inhibition of gap junctional intercellular communication by the green tea polyphenol (-)-epigallocatechin gallate in normal rat liver epithelial cells.

@article{Kang2008InhibitionOG,
  title={Inhibition of gap junctional intercellular communication by the green tea polyphenol (-)-epigallocatechin gallate in normal rat liver epithelial cells.},
  author={Nam Joo Kang and Kyung Mi Lee and Jong Hun Kim and Bo Kyung Lee and Jung Yeon Kwon and Ki Won Lee and Hyong Joo Lee},
  journal={Journal of agricultural and food chemistry},
  year={2008},
  volume={56 21},
  pages={10422-7}
}
(-)-Epigallocatechin gallate (EGCG), a polyphenolic compound found in green tea, is a promising chemopreventive agent against cancer due to its strong antiproliferative effects on cancer cells; however, its possible toxicity and carcinogenicity must be investigated before EGCG can be used as a dietary supplement for chemoprevention. The inhibition of gap junctional intercellular communication (GJIC) is strongly associated with carcinogenesis, particularly the tumor promotion process; thus, we… CONTINUE READING

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