Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro.

@article{Schiller2001InhibitionOG,
  title={Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro.},
  author={Paul C. Schiller and Gianluca D’Ippolito and Roberta Brambilla and Bernard A. Roos and Guy A. Howard},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={
          14133-8
        }
}
Osteoblasts and adipocytes are thought to differentiate from a common stromal progenitor cell. These two phenotypically mature cell types show a high degree of plasticity, which can be observed when cells are grown under specific culture conditions. Gap junctions are abundant among osteoblastic cells in vivo and in vitro, whereas they are down-regulated during adipogenesis. Gap junctional communication (GJC) modulates the expression of genes associated with the mature osteoblastic phenotype… CONTINUE READING

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