• Corpus ID: 2248088

Inhibition of gamma-aminobutyric acid release from synaptosomes by local anesthetics.

@article{Ikeda1983InhibitionOG,
  title={Inhibition of gamma-aminobutyric acid release from synaptosomes by local anesthetics.},
  author={Masahiro Ikeda and Toshihiro Dohi and Akira Tsujimoto},
  journal={Anesthesiology},
  year={1983},
  volume={58 6},
  pages={
          495-9
        }
}
The effects of local anesthetics on the synthesis, release, and degradation of gamma-aminobutyric acid (GABA) in rat brains were investigated. The addition of procaine, lidocaine, cocaine, or tetracaine did not alter either glutamic acid decarboxylase (GAD) activity or GABA transaminase (GABA-T) activity in vitro. Neither did the enzyme activities in rats with local anesthetic-induced convulsions differ from control values. Tetracaine inhibited high K+-evoked [2,3-3H]GABA release from… 
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