Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

@article{Hallenberger1992InhibitionOF,
  title={Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60},
  author={S. Hallenberger and V. Bosch and H. Angliker and E. Shaw and H. Klenk and W. Garten},
  journal={Nature},
  year={1992},
  volume={360},
  pages={358-361}
}
THE envelope glycoprotein of human immunodeficiency virus (HIV) initiates infection1 by mediating fusion of the viral envelope with the cell membrane. Fusion activity requires proteolytic cleavage of the gp160 protein into gp120 and gp41 at a site containing several arginine and lysine residues2. Activation at basic cleavage sites is observed with many membrane proteins of cellular and viral origin. We have recently found that the enzyme activating the haemagglutinin of fowl plague virus (FPV… Expand
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Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.
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