Inhibition of food intake by central injection of anti-orexin antibody in fasted rats.

@article{Yamada2000InhibitionOF,
  title={Inhibition of food intake by central injection of anti-orexin antibody in fasted rats.},
  author={Hiroto Yamada and Toshikatsu Okumura and Wataru Motomura and Yasuhito Kobayashi and Yutaka Kohgo},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={267 2},
  pages={527-31}
}
It has been shown that intracerebroventricular injection of synthetic orexins stimulated food intake in rats. This pharmacological evidence suggests that orexins may have a role for the central regulation of feeding. In the present study, we investigated the hypothesis of whether endogenous orexins indeed play a vital role in feeding behavior. An anti-orexin polyclonal antibody was used throughout the study. First, we examined the specificity of the antibody to orexin by Western blot analysis… CONTINUE READING

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