Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.

@article{Dias2013InhibitionOF,
  title={Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.},
  author={J. A. Travassos Dias and Brice Campo and Barbara Jean Alexander Weaver and Julie Watts and Kerri S. Kluetzman and Richard May Thomas and B{\'e}atrice Bonnet and Vincent Mutel and Sonia Maria Poli},
  journal={Biology of reproduction},
  year={2013},
  volume={90 1},
  pages={
          19
        }
}
We previously described a negative allosteric modulator (NAM) of FSHR (ADX61623) that blocked FSH-induced cAMP and progesterone production but did not block estradiol production. That FSHR NAM did not affect FSH-induced preovulatory follicle development as evidenced by the lack of an effect on the number of FSH-dependent oocytes found in the ampullae following ovulation with hCG. A goal is the development of a nonsteroidal contraceptive. Toward this end, a high-throughput screen using human… CONTINUE READING
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