Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

@article{Gilmore1996InhibitionOF,
  title={Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.},
  author={Andrew P Gilmore and Lewis H. Romer},
  journal={Molecular biology of the cell},
  year={1996},
  volume={7 8},
  pages={1209-24}
}
It has been proposed that the focal adhesion kinase (FAK) mediates focal adhesion formation through tyrosine phosphorylation during cell adhesion. We investigated the role of FAK in focal adhesion structure and function. Loading cells with a glutathione-S-transferase fusion protein (GST-Cterm) containing the FAK focal adhesion targeting sequence, but not the kinase domain, decreased the association of endogenous FAK with focal adhesions. This displacement of endogenous FAK in both BALB/c 3T3… CONTINUE READING

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