Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation.

@article{Dehlin2011InhibitionOF,
  title={Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation.},
  author={Mats Dehlin and Sofia E. M. Andersson and Malin C Erlandsson and Mikael Brisslert and Maria Bokarewa},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 4},
  pages={811-7}
}
TKs are intracellular signaling molecules essential for cell homeostasis. Inhibition of TKs is used in treatment of malignancies and diabetes mellitus. The present study evaluated the role of Flt3 in antigen-induced arthritis. Mice were immunized with mBSA, and arthritis was induced by an i.a. injection of mBSA. Treatment with the Flt3 inhibitor sunitinib was started together with mBSA immunization or together with the induction of arthritis. The mBSA-injected joints were evaluated… CONTINUE READING

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