Inhibition of flavonoids on acetylcholine esterase: binding and structure-activity relationship.

@article{Xie2014InhibitionOF,
  title={Inhibition of flavonoids on acetylcholine esterase: binding and structure-activity relationship.},
  author={Yixi Xie and Weijie Yang and Xiao-qing Chen and Jianbo Xiao},
  journal={Food & function},
  year={2014},
  volume={5 10},
  pages={2582-9}
}
The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers. However, few reports have focused on the structure-activity relationship for AChE inhibition of flavonoids. This work mainly concerns the structural aspects of inhibitory activities and binding affinities of flavonoids as AChE inhibitors. The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the… CONTINUE READING