Inhibition of filovirus replication by the zinc finger antiviral protein.

  title={Inhibition of filovirus replication by the zinc finger antiviral protein.},
  author={Stefanie M{\"u}ller and Peggy M{\"o}ller and Matthew J. Bick and Stephanie Wurr and Stephan Becker and Stephan G{\"u}nther and Beate Mareike K{\"u}mmerer},
  journal={Journal of virology},
  volume={81 5},
The zinc finger antiviral protein (ZAP) was recently shown to inhibit Moloney murine leukemia virus and Sindbis virus replication. We tested whether ZAP also acts against Ebola virus (EBOV) and Marburg virus (MARV). Antiviral effects were observed after infection of cells expressing the N-terminal part of ZAP fused to the product of the zeocin resistance gene (NZAP-Zeo) as well as after infection of cells inducibly expressing full-length ZAP. EBOV was inhibited by up to 4 log units, whereas… CONTINUE READING


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