Inhibition of feeding by ACTH-(1-24): behavioral and pharmacological aspects.

@article{Vergoni1990InhibitionOF,
  title={Inhibition of feeding by ACTH-(1-24): behavioral and pharmacological aspects.},
  author={Anna Valeria Vergoni and R. Poggioli and D Marrama and Alfio Bertolini},
  journal={European journal of pharmacology},
  year={1990},
  volume={179 3},
  pages={347-55}
}
The time course of the behavior of rats fasted for 24 h was analyzed with observation starting either 10 or 60 min after the i.c.v. administration of ACTH-(1-24) (4 micrograms/animal). The anorectic effect of this peptide was direct and specific because it could be dissociated in time from the grooming-inducing effect. The effect is a central one, not linked either to an interaction with the peripheral feeding-regulatory system, or to the release of adrenal steroids. ACTH-(1-24), like… CONTINUE READING