Inhibition of fatty acid synthetases by the antibiotic cerulenin.

@article{Vance1972InhibitionOF,
  title={Inhibition of fatty acid synthetases by the antibiotic cerulenin.},
  author={D. Vance and I. Goldberg and O. Mitsuhashi and K. Bloch},
  journal={Biochemical and biophysical research communications},
  year={1972},
  volume={48 3},
  pages={
          649-56
        }
}
Abstract The antibiotic cerulenin is a potent and apparently non-competitive inhibitor of fatty acid synthetase systems isolated from various microorganisms and from rat liver. Cerulenin specifically blocks the activity of β-keto acyl thioester synthetase (condensing enzyme). This effect may account for the inhibition of overall fatty acid synthesis by the antibiotic. 
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