Inhibition of fatty acid synthetases by the antibiotic cerulenin.

@article{Vance1972InhibitionOF,
  title={Inhibition of fatty acid synthetases by the antibiotic cerulenin.},
  author={D. Vance and I. Goldberg and O. Mitsuhashi and K. Bloch},
  journal={Biochemical and biophysical research communications},
  year={1972},
  volume={48 3},
  pages={
          649-56
        }
}
Abstract The antibiotic cerulenin is a potent and apparently non-competitive inhibitor of fatty acid synthetase systems isolated from various microorganisms and from rat liver. Cerulenin specifically blocks the activity of β-keto acyl thioester synthetase (condensing enzyme). This effect may account for the inhibition of overall fatty acid synthesis by the antibiotic. 
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Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast.
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The effect of cerulenin on sterol biosynthesis inSaccharomyces cerevisiae
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Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase.
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Effect of side-chain structure on inhibition of yeast fatty-acid synthase by cerulenin analogues.
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Structure of the Complex between the Antibiotic Cerulenin and Its Target, β-Ketoacyl-Acyl Carrier Protein Synthase*
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Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings.
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References

SHOWING 1-7 OF 7 REFERENCES
Mycobacterium phlei Fatty Acid Synthetase—A Bacterial Multienzyme Complex
  • 94
Acyl carrier protein from Mycobacterium phlei.
  • 27
Fatty acid synthetases from Euglena gracilis.
  • 71
Biosynthesis of Fatty Acids I. STUDIES WITH ENZYMES OBTAINED FROM LIVER
  • 199
  • PDF
The antibacterial activity of 3-decynoyl-n-acetylcysteamine. Inhibition in vivo of beta-hydroxydecanoyl thioester dehydrase.
  • L. Kass
  • Medicine, Chemistry
  • The Journal of biological chemistry
  • 1968
  • 60
Comparative studies of the pigeon liver fatty acid synthetase complex and its subunits. Kinetics of partial reactions and the number of binding sites for acetyl and malonyl groups.
  • 105
Studies on cerulenin. VI. Some spectroscopic features of cerulenin.
  • 11