Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis

@article{Zecchin2011InhibitionOF,
  title={Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis},
  author={Karina Gotardelo Zecchin and Franco A Rossato and Helena F. Raposo and Daniela Rodrigues De Melo and Luciane Carla Alberici and Helena C F Oliveira and Roger F Castilho and Ricardo D Coletta and Anibal E Vercesi and Edgard Graner},
  journal={Laboratory Investigation},
  year={2011},
  volume={91},
  pages={232-240}
}
Fatty acid synthase (FASN) is the metabolic enzyme responsible for the endogenous synthesis of the saturated long-chain fatty acid, palmitate. In contrast to most normal cells, FASN is overexpressed in a variety of human cancers, including cutaneous melanoma, in which its levels of expression are associated with tumor invasion and poor prognosis. We have previously shown that FASN inhibition with orlistat significantly reduces the number of spontaneous mediastinal lymph node metastases… CONTINUE READING

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