Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey.

@article{Kawahara2011InhibitionOF,
  title={Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey.},
  author={Hitoshi Kawahara and Geoffrey M Drew and Macdonald J Christie and Christopher W Vaughan},
  journal={British journal of pharmacology},
  year={2011},
  volume={163 6},
  pages={1214-22}
}
BACKGROUND AND PURPOSE While arachidonyl ethanolamine (anandamide) produces pharmacological effects mediated by cannabinoid CB1 receptors, it is also an agonist at the transient receptor potential vanilloid type 1 (TRPV1) ion channel. This study examined the cellular actions of anandamide in the midbrain periaqueductal grey (PAG), a region implicated in the analgesic actions of cannabinoids, and which expresses both CB1 receptors and TRPV1. EXPERIMENTAL APPROACH In vitro whole cell patch… CONTINUE READING

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