Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats.

Abstract

BACKGROUND AND PURPOSE Factor Xa (FXa) is a key coagulation protease and target for novel antithrombotic agents for prevention and treatment of diverse thromboembolic disorders. In the present study we describe the effect of a novel, potent, and selective FXa inhibitor, DPC602, on brain damage and neurobehavioral consequence in a rat thromboembolic model of… (More)

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