Inhibition of fMLP-triggered respiratory burst of human monocytes by adenosine: involvement of A3 adenosine receptor.

@article{Broussas1999InhibitionOF,
  title={Inhibition of fMLP-triggered respiratory burst of human monocytes by adenosine: involvement of A3 adenosine receptor.},
  author={Matthieu Broussas and Pascale Cornillet-Lef{\`e}bvre and G{\'e}rard Potron and Phuong Th{\^e} Nguy{\^e}n},
  journal={Journal of leukocyte biology},
  year={1999},
  volume={66 3},
  pages={495-501}
}
Adenosine (Ado) is a potent anti-inflammatory agent acting on a variety of cell functions. However, its effects on human monocytes have been less well characterized. We investigated the effect of Ado and its receptor-specific analogs on NADPH oxidase activity with the use of luminol-enhanced chemiluminescence (CL). Adenosine inhibited fMLP-triggered NADPH oxidase activity with a maximal inhibition of 55+/-5%. IB-MECA, a selective A3 Ado receptor agonist reduced fMLP triggered NADPH oxidase… CONTINUE READING

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