Inhibition of extracellular signal-regulated kinase 1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression.

@article{Seddighzadeh2000InhibitionOE,
  title={Inhibition of extracellular signal-regulated kinase 1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression.},
  author={Maria Seddighzadeh and Stig Linder and Maria C. Shoshan and Gert Auer and Ayodele A. Alaiya},
  journal={Electrophoresis},
  year={2000},
  volume={21 13},
  pages={
          2737-43
        }
}
Biochemical and genetic strategies have implied that aberrant signaling in the extracellular signal-regulated kinase (ERK)/mitogen-activated protein (MAP) kinase pathway contributes significantly to transformed phenotypes. Using PD98059, an inhibitor of the ERK-kinase MEK1, we have here assessed the effects of ERK inhibition on the pattern of protein expression in the metastatic human breast cancer cell line MDA-MB-231. At a concentration of inhibitor which did not significantly affect cell… CONTINUE READING
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