Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites.

@article{Rice2001InhibitionOE,
  title={Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites.},
  author={P L Rice and R J Goldberg and E C Ray and Linda J Driggers and Dennis J. Ahnen},
  journal={Cancer research},
  year={2001},
  volume={61 4},
  pages={1541-7}
}
  • P L Rice, R J Goldberg, +2 authors Dennis J. Ahnen
  • Published 2001 in Cancer research
Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac is associated with a decreased mortality from colorectal cancer. Sulindac causes regression of precancerous adenomatous polyps and inhibits the growth of cultured colon cell lines. Whereas induction of apoptotic cell death is thought to account for the growth inhibitory effect of sulindac, less is known about its biochemical mechanism(s) of action. Sulindac is metabolized in vivo to sulfide and sulfone… CONTINUE READING