Inhibition of experimental colon cancer metastasis by the GABA-receptor agonist nembutal.


Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter, and GABA receptors have been recently detected on epithelial colon cancer cells. Nembutal (pentobarbital) is a barbiturate with GABA-agonistic effects. We demonstrate that GABA receptors are present on colon cancer cell lines (KM12SM, HT29, RKO). Nembutal (0.1-500 microg/ml) continuous… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.