Inhibition of experimental choroidal neovascularization by an anti-growth agent inhibiting vascular endothelial development.

@article{Matsuo2003InhibitionOE,
  title={Inhibition of experimental choroidal neovascularization by an anti-growth agent inhibiting vascular endothelial development.},
  author={Yoko Matsuo and Yutao Li and Hiroyasu Taniguchi and Masanori Motoda and Tsugio Amemiya},
  journal={Japanese journal of ophthalmology},
  year={2003},
  volume={47 5},
  pages={
          454-8
        }
}
PURPOSE To determine whether FR118487, a recently developed angiogenesis inhibitor, affects experimental choroidal neovascularization (CNV) induced by laser photocoagulation in pigmented rats. METHODS Focal laser photocoagulation (argon green 50 mW, 0.04 seconds, 200 microm) was applied to the retinochoroid of normal Brown Norway rats. Systemic administration of FR118487 (1.0 mg/kg body weight per day) with a mini-osmotic pump implanted in the subcutaneous tissue of the neck was started just… CONTINUE READING