Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10 gene.

@article{Kozak2002InhibitionOE,
  title={Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10 gene.},
  author={Yvonne de Kozak and Brigitte Thillaye-Goldenberg and M. F. Naud and Annaelle Da Costa and Claude Auriault and Claudie Verwaerde},
  journal={Clinical and experimental immunology},
  year={2002},
  volume={130 2},
  pages={212-23}
}
Pathological ocular manifestations result from a dysregulation in the balance between proinflammatory type 1 cytokines and regulatory type 2 cytokines. Interleukin-10 (IL-10) is an anti-inflammatory cytokine with potent immunosuppressive effects. We have examined the efficiency of viral IL-10 adenovirus (Ad-vIL-10)-mediated gene transfer on experimental autoimmune uveoretinitis (EAU) induced in mice and rats by purified retinal autoantigens, respectively, interphotoreceptor binding protein… CONTINUE READING

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