Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum.

@article{MurakamiMurofushi1992InhibitionOE,
  title={Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum.},
  author={Kimiko Murakami-Murofushi and Mieko Shioda and Keisuke Kaji and Satoshi Yoshida and Hiromu Murofushi},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 30},
  pages={21512-7}
}
A specific inhibitor of DNA polymerase alpha was isolated from the lipid fraction prepared from myxoamoebae of a true slime mold, Physarum polycephalum. The purified substance was subjected to structural studies by fast atom bombardment mass spectroscopy, infrared spectroscopy, and two-dimensional nuclear magnetic resonance spectroscopy. The structure of this substance was thereby suggested to be a novel lysophosphatidic acid (LPA) composed of cyclic phosphate and cyclopropane-containing… CONTINUE READING