Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass

@article{Klinke2004InhibitionOE,
  title={Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass},
  author={Helene Bendstrup Klinke and Anne Belinda Thomsen and Birgitte Kiaer Ahring},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={66},
  pages={10-26}
}
An overview of the different inhibitors formed by pre-treatment of lignocellulosic materials and their inhibition of ethanol production in yeast and bacteria is given. Different high temperature physical pre-treatment methods are available to render the carbohydrates in lignocellulose accessible for ethanol fermentation. The resulting hydrolyzsates contain substances inhibitory to fermentation—depending on both the raw material (biomass) and the pre-treatment applied. An overview of the… 
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    Applied Microbiology and Biotechnology
  • 2006
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This suggests that during the lag phase, ethanologenic yeasts undergo a genomic adaptation process in response to the inhibitors, which provides a strong foundation for future studies on genomic adaptation and manipulation of yeast to aid more robust strain design and development.
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Results indicate that the contamination by bacteria when fermenting at high pH can be prevented effectively using hydrolysates with total solids of more than 20%.
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Molecular Adaptation Mechanisms Employed by Ethanologenic Bacteria in Response to Lignocellulose-derived Inhibitory Compounds
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Understanding the molecular adaptation mechanisms of ethanologenic bacteria in response to lignocellulose-derived inhibitory compounds will be essential in the design of 'intelligent' metabolic engineering strategies for the generation of hyper-tolerant fermentation bacteria strains.
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