Inhibition of epidermal metabolism and DNA-binding of benzo[a]pyrene by ellagic acid.

@article{Tito1983InhibitionOE,
  title={Inhibition of epidermal metabolism and DNA-binding of benzo[a]pyrene by ellagic acid.},
  author={B J Del Tito and Hasan Mukhtar and David R. Bickers},
  journal={Biochemical and biophysical research communications},
  year={1983},
  volume={114 1},
  pages={388-94}
}
Ellagic acid, a common plant phenol, was shown to be a potent inhibitor of epidermal microsomal aryl hydrocarbon hydroxylase (AHH) activity in vitro, and of benzo[a]pyrene (BP)-binding to both calf thymus DNA in vitro and to epidermal DNA in vivo. The in vitro addition of ellagic acid (0.25-2.0 microM) resulted in a dose-dependent inhibition of AHH activity in epidermal microsomes prepared from control or carcinogen-treated animals. The I50 of ellagic acid for epidermal AHH was 1.0 microM… CONTINUE READING

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