Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice

@article{Lorch2007InhibitionOE,
  title={Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice},
  author={Gwendolen Lorch and Jennifer L. Gilmore and Peter F Koltz and Ryan M Gonterman and R Laughner and Davina A. Lewis and Raymond L. Konger and Kiran S Nadella and Ramiro E. Toribio and Thomas J Rosol and John Foley},
  journal={British Journal of Cancer},
  year={2007},
  volume={97},
  pages={183 - 193}
}
The purpose of this study was to evaluate the role of the epidermal growth factor receptor (EGFR) in parathyroid hormone-related protein (PTHrP) expression and humoral hypercalcaemia of malignancy (HHM), using two different human squamous-cell carcinoma (SCC) xenograft models. A randomised controlled study in which nude mice with RWGT2 and HARA xenografts received either placebo or gefitinib 200 mg kg−1 for 3 days after developing HHM. Effectiveness of therapy was evaluated by measuring plasma… CONTINUE READING
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