Inhibition of enzyme activities by 12-keto oleic acid.

  title={Inhibition of enzyme activities by 12-keto oleic acid.},
  author={M. Sato and M. Uchiyama},
  journal={Chemical & pharmaceutical bulletin},
  volume={20 4},
  • M. Sato, M. Uchiyama
  • Published 1972
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • The effect of the long chain keto acid, which is one of the secondary products from oxidative deteriolation of lipids, on the enzyme activity was investigated in vitro. Cholinesterase and succinate dehydrogenase were inhibited more effectively by 12-keto oleic than by linoleic acid, whereas the inhibition of trypsin by linoleic acid was greater than that caused by 12-keto oleic acid. This fact may show that the enzyme inhibition 12-keto oleic acid is not merely due to nonspecific denaturation… CONTINUE READING
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