Inhibition of entire myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats by major histocompatibility complex class II-binding competitor peptides.

@article{Wauben1994InhibitionOE,
  title={Inhibition of entire myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats by major histocompatibility complex class II-binding competitor peptides.},
  author={Marca H. M. Wauben and A G Kozhich and Irma Joosten and A Schlief and Claire J. P. Boog and Willem van Eden},
  journal={European journal of immunology},
  year={1994},
  volume={24 5},
  pages={1053-60}
}
Previous studies have shown that major histocompatibility complex (MHC) blockade by competitor peptides with high MHC class II binding affinity can prevent peptide-induced experimental autoimmune encephalomyelitis (EAE). However, none of these studies addressed the question whether this approach could also be used to prevent EAE induced with a multivalent antigen. In this report we show the effect of competitor peptides co-immunized during EAE induction with entire guinea pig myelin basic… CONTINUE READING