Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k.

@article{Wang2017InhibitionOE,
  title={Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k.},
  author={Yaxin Wang and Lin Cao and Yangyang Zhai and Jiaming Ma and Quandeng Nie and Ting Li and Zheng Yin and Yuna Sun and Luqing Shang},
  journal={Antiviral research},
  year={2017},
  volume={141},
  pages={
          91-100
        }
}
Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Based on our previous report of a peptide-aldehyde anti-EV71 protease, we present here a highly specific α-hydroxy-nitrile derivative NK-1.9k, which inhibited the proliferation of multiple EV71… CONTINUE READING

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