Inhibition of enterotoxin-induced porcine colonic secretion by diarylsulfonylureas in vitro.

@article{ODonnell2000InhibitionOE,
  title={Inhibition of enterotoxin-induced porcine colonic secretion by diarylsulfonylureas in vitro.},
  author={E. K. O'Donnell and Roger L. Sedlacek and A. K. Singh and Bruce D. Schultz},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={279 5},
  pages={
          G1104-12
        }
}
Muscle-stripped piglet colon was used to evaluate changes in short-circuit current (I(sc)) as an indicator of anion secretion. Mucosal exposure to Escherichia coli heat-stable (STa) or heat-labile enterotoxins (LT) stimulated I(sc) by 32 +/- 5 and 42 +/- 7 microA/cm(2), respectively. Enterotoxin-stimulated I(sc) was not significantly affected by either 4,4'-diaminostilbene-2, 2'-disulfonic acid or CdCl(2), inhibitors of Ca(2+)-activated Cl(-) channels and ClC-2 channels, respectively… 

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