Inhibition of energy metabolism by 3-nitropropionic acid activates ATP-sensitive potassium channels.

@article{Riepe1992InhibitionOE,
  title={Inhibition of energy metabolism by 3-nitropropionic acid activates ATP-sensitive potassium channels.},
  author={M. Riepe and Nobuaki Hori and Albert Christian Ludolph and D. E. O. S. Carpenter and Peter S. Spencer and Charles N. Allen},
  journal={Brain research},
  year={1992},
  volume={586 1},
  pages={61-6}
}
3-Nitropropionic acid (1 mM), which inhibits succinate dehydrogenase activity and reduces cellular energy, produces in the pyramidal cell layer of the hippocampal region CA1 a hyperpolarization for variable lengths of time before evoking an irreversible depolarization. Hyperpolarization is caused by an increased potassium conductance that is attenuated by glibenclamide (1-10 microM), a selective antagonist of ATP-sensitive potassium channels; in contrast, diazoxide (0.5 mM), an agonist at this… CONTINUE READING
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