Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist.

@article{Mullarkey2003InhibitionOE,
  title={Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist.},
  author={Maureen Mullarkey and Jeffrey R. Rose and John R. Bristol and Tsutomu Kawata and Akufumi Kimura and Seiichi Kobayashi and Melinda Przetak and Jesse C. Chow and Fabi{\'a}n Gusovsky and William J. Christ and Daniel P. Rossignol},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={304 3},
  pages={1093-102}
}
Alpha-D-glucopyranose,3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-1-(dihydrogen phosphate), tetrasodium salt (E5564) is a second-generation synthetic lipodisaccharide designed to antagonize the toxic effects of endotoxin, a major immunostimulatory component of the outer cell membrane of Gram negative bacteria. In vitro, E5564 dose dependently (nanomolar… CONTINUE READING
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E 5564 blocks responses to endotoxin in normal volunteers with experimental endotoxemia

  • AE Martinez-Pellus, P Merino, +6 authors B Alvarez
  • J Infect Dis
  • 2003

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