Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins

@article{Short2005InhibitionOE,
  title={Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins},
  author={Sarah M. Short and Alexandrine Derrien and Radha P. Narsimhan and Jack W Lawler and Donald E. Ingber and Bruce R. Zetter},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={168},
  pages={643 - 653}
}
The anti-angiogenic effect of thrombospondin-1 has been shown to be mediated through binding of the type-1 repeat (TSR) domain to the CD36 transmembrane receptor. We now report that the TSR domain can inhibit VEGF-induced migration in human umbilical vein endothelial cells (HUVEC), cells that lack CD36. Moreover, we identified beta1 integrins as a critical receptor in TSR-mediated inhibition of migration in HUVEC. Using pharmacological inhibitors of downstream VEGF receptor effectors, we found… CONTINUE READING

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