Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center.

@article{Hotchkiss2002InhibitionOE,
  title={Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center.},
  author={Kylie A. Hotchkiss and Anthony W Ashton and Radma Mahmood and R. Graham G. Russell and Joseph A Sparano and Edward L. Schwartz},
  journal={Molecular cancer therapeutics},
  year={2002},
  volume={1 13},
  pages={1191-200}
}
A number of cancer chemotherapeutic drugs designed to have cytotoxic actions on tumor cells have recently been shown to also have antiangiogenic activities. Endothelial cell migration and proliferation are key components of tumor angiogenesis, and agents that target the microtubule cytoskeleton can interfere with these processes. In this study, the effect on endothelial cell functions of the microtubule-stabilizing drugs Taxotere and Taxol were evaluated in three in vitro assays: a chemokinetic… CONTINUE READING

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