Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells.

@article{Misinzo2008InhibitionOE,
  title={Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells.},
  author={Gerald Misinzo and Peter Delputte and Hans Nauwynck},
  journal={Journal of virology},
  year={2008},
  volume={82 3},
  pages={1128-35}
}
Recently, Misinzo et al. (G. Misinzo, P. Meerts, M. Bublot, J. Mast, H. M. Weingartl, and H. J. Nauwynck, J. Gen. Virol. 86:2057-2068, 2005) reported that inhibiting endosome-lysosome system acidification reduced porcine circovirus 2 (PCV2) infection of monocytic 3D4/31 cells. The present study examined the effect of inhibiting endosome-lysosome system acidification in epithelial cells, since epithelial cells support PCV2 infection in vivo and are used in culturing PCV2 in vitro. Ammonium… CONTINUE READING

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