Inhibition of endometrial carcinoma cell growth using antisense estrogen receptor oligodeoxyribonucleotides.

@article{Taylor2002InhibitionOE,
  title={Inhibition of endometrial carcinoma cell growth using antisense estrogen receptor oligodeoxyribonucleotides.},
  author={Anthony Henry Taylor and Farook al-Azzawi and James Howard Pringle and Stephen Charles Bell},
  journal={Anticancer research},
  year={2002},
  volume={22 6C},
  pages={3993-4003}
}
BACKGROUND The sex hormone 17 beta-estradiol acts as a mitogen in a number of tissues, including the endometrium, through direct interaction with the estrogen receptor (ER alpha). In the protection of the female breast and endometrium from cancer progression it would be advantageous to inhibit estrogenic action, therefore many estrogen receptor antagonists have been made. However, the most clinically relevant anti-estrogens for breast cancer have a detrimental effect on the endometrium and… CONTINUE READING